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KMID : 0894520190230020129
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Development & Reproduction
2019 Volume.23 No. 2 p.129 ~ p.138
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Anti-obesity Activity of Ethanol Extract from Bitter Melon in Mice Fed High-Fat Diet
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Yoon Nal-Ae
Park Ju-Yeong
Jeong Joo-Yeon
Rashidova Nilufar
Ryu Jin-Hyun
Roh Gu-Seob
Kim Hyun-Joon
Cho Gyeong-Jae
Choi Wan-Sung
Lee Dong-Hoon
Kang Sang-Soo
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Abstract
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In many cases, obesity is associated with metabolic disorders. Recently, natural compounds that may be beneficial for improving obesity have received increasing attention. Bitter melon has received attention as a diabetes treatment. NAD+-dependent deacetylase (Sirtuin 1, SIRT1) has emerged as a novel therapeutic target for metabolic diseases. In this study, ethanol extract of bitter melon (BME) suppressed adipocyte differentiation and significantly increased the expression of SIRT1 in fully differentiated 3T3-L1 cells. Moreover, it enhanced the activation of AMP-activated protein kinase (AMPK). In high-fat diet (HFD)-fed induced-obesity mice, BME suppressed HFD-induced increases in body weight and white adipose tissue (WAT) weight. BME also increased the expression of SIRT1 and suppressed peroxisome proliferator-activated receptor and sterol regulatory element binding protein 1 expressions of WAT from HFD-fed mice. These findings suggest that BME prevents obesity by activating the SIRT1 and AMPK pathway and that it may be a useful dietary supplement for preventing obesity.
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KEYWORD
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Bitter melon, High-fat diet, Obesity, 3T3-L1, Sirtuin 1
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